Resources

Resources

Embic engages in continuous scientific activity and shares its advancements through peer-reviewed scientific publications, conference presentations, research collaboration, and white papers.

Peer-Reviewed Publications: Methodologies and Technologies
Embic’s research & development efforts are published from peer-reviewed scientific journals.

Selected List

Bock JR, Russell J, Hara J, Fortier D. Optimizing Cognitive Assessment Outcomes for Alzheimer’s Disease by Matching Wordlist Memory Test Features to Scoring Methodology. Front. Digit. Health, 03 November 2021. https://doi.org/10.3389/fdgth.2021.750549
Bock JR, Hara J, Fortier D, Lee MD, Petersen RC, Shankle WR, The Alzheimer’s Disease Neuroimaging Initiative. Application of Digital Cognitive Biomarkers for Alzheimer’s Disease: Toward Predicting Impending Cognitive Decline. JPAD. 2020. Published online November 11, 2020, http://dx.doi.org/10.14283/jpad.2020.63
Lee MD, Bock JR, Cushman I, Shankle WR. An application of multinomial processing tree models and Bayesian methods to understanding memory impairment. J Math Psychol. 2020. 95;102328.
Alexander GE, Satalitch TA, Shankle WR, Batchelder WH. A Cognitive Psychometric Model for Psychodiagnostic Assessment of Memory Deficit Disorders. Psych Assessment. 2016;28(3):279-93.
Lee MD, Abramyan MD, Shankle WR. Semantic Structure and Memory Impairment: New Methods, Measures, and Models for Analyzing Triadic Comparisons. Behavior Research Methods. Behav Res Methods. Behav Res Methods. 2016;48(4):1492-1507.
Shankle WR, Hara J, Mangrola M, Alva G, Lee MD. Generative Modeling Methods For Analyzing Clinical Trial Data: Hierarchical Bayesian Cognitive Processing Models. Alzheimer’s & Dementias. 2013;9:422-428.
Shankle WR, Pooly J, Steyvers M, Hara J, Mangrola T, Reisberg B, Lee MD. Relating Memory To Functional Capacity In Normal Aging to Dementia Using Hierarchical Bayesian Cognitive Processing Models. ADAD. 2013;27(1):16-22.
Hachinski V, Oveisgharan S, Romney AK, Shankle WR. Optimizing The Hachinski Ischemic Scale. Archives of Neurology. 2012;69(2):169-175.
Pooley JP, Lee MD, Shankle WR. Understanding Alzheimer’s using memory models and hierarchical Bayesian analysis. Journal of Mathematical Psychology. 2011;55:47-56.
Rafii M, Taylor C, Coutinho A, Kim K, Galasko D. Comparison of the memory performance index with standard neuropsychological measures of cognition. Am J Alzheimers Dis Other Demen. 2011;26(3):235-9.
Shankle WR, Mangrola T, Chan T, Hara J. Development and Validation of the Memory Performance Index: Reducing Measurement Error in Recall Tests. Alzheimer’s & Dementia. 2009;5:295–306.
Cho A, Sugimura M, Nakano S, Yamada T. The Japanese MCI Screen for Early Detection of Alzheimer’s Disease and Related Disorders. American Journal of Alzheimer’s Disease and Other Dementias. 2008;23(2):162-166.
Trenkle D, Shankle WR, Azen SP. Detecting Cognitive Impairment in Primary Care: Performance Assessment of Three Screening Instruments. Journal of Alzheimer’s Disease. 2007;11(3):323-335.
Cho A, Sugimura M, Nakano S, Yamada T. Early Detection and Diagnosis of MCI Using the MCI Screen Test. The Japanese Journal of Clinical and Experimental Medicine. 2007;84(8):1152-1160.
Shankle WR, Romney AK, Hara J, et al. Method to improve the detection of mild cognitive impairment. PNAS. 2005;102(13):4919-24.

Peer-Reviewed Publications: Applications
Embic’s digital cognitive biomarkers are used in many different academic and industry studies.

Selected List

Noguchi-Shinohara M, Yokoyama K, Komatsu J, Masuda K, Kouno M, Yoshita M, Ono K. Exercise program to reduce the risk of cognitive decline and physical frailty in older adults: study protocol for an open label double-arm clinical trial. Front. Aging Neurosci.,19 May 2023. https://doi.org/10.3389/fnagi.2023.1162765
Roach JC, Hara J, Fridman D, Lovejoy JC, Jade K, Heim L, Romansik R, Swietlikowski A, Phillips S, Rapozo MK, Shay MA, Fischer D, Funk C, Dill L, Brant-Zawadzki M, Hood L, Shankle WR. The Coaching for Cognition in Alzheimer’s (COCOA) trial: Study design. Alzheimers Dement (N Y). 2022 Jul 26;8(1):e12318. doi: 10.1002/trc2.12318.
Xiao J, Katsumata N, Bernier F, Ohno K, Yamauchi Y, Odamaki T, Yoshikawa K, Ito K, Kaneko T. Probiotic Bifidobacterium breve in Improving Cognitive Functions of Older Adults with Suspected Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2020;77(1):139-147.
Kokubun K, Nemoto K, Yamakawa, Y. Fish Intake May Affect Brain Structure and Improve Cognitive Ability in Healthy People. Front. Aging Neurosci. 2020;12:76.
Ogawa M, Maruo K, Sone D, Shimada H, Suzuki K, Watanabe H, Matsuda H, Mizusawa H. Longitudinal analysis of risk factors for dementia based on Mild Cognitive Impairment Screen results and questionnaire responses from healthy Japanese individuals registered in an online database. Alzheimers Dement (N Y). 2019;5:347-353.
Koizumi S, Inoue N, Sugihara F, Igase M. Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study. Nutrients. 2019;12(1).
Igase M, Igase K, Tabara Y, Ohyagi Y, Kohara K. Cross-sectional study of equol producer status and cognitive impairment in older adults. Geriatr Gerontol Int. 2017;17(11):2103-2108.
Ogawa M, Sone D, Maruo K, Shimada H, Suzuki K, Watanabe H, Matsuda H, Mizusawa H. Analysis of risk factors for mild cognitive impairment based on word list memory test results and questionnaire responses in healthy Japanese individuals registered in an online database. PLoS One. 2018;13(5):e0197466.
Igase M, Okada Y, Ochi M, Igase K, Ochi H, Okuyama S, Furukawa Y, Ohyagi Y. Auraptene in the Peels of Citrus Kawachiensis (Kawachibankan) Contributes to the Preservation of Cognitive Function: A Randomized, Placebo-Controlled, Double-Blind Study in Healthy Volunteers. J Prev Alzheimers Dis. 2018;5(3):197-201.
Ohara M, Kohara K, Okada Y, Ochi M, Nagai T, Ohyagi Y, Tabara Y, Igase M. Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study. Sci Rep. 2017;7:46419.
Igase M, Ohara M, Igase K, Kato T, Okada Y, Ochi M, Tabara Y, Kohara K, Ohyagi Y. Skin Autofluorescence Examination as a Diagnostic Tool for Mild Cognitive Impairment in Healthy People. J Alzheimers Dis. 2017;55(4):1481-1487.
Hara J, Shankle WR, Barrentine L, Curole M. Novel Therapy of Hyperhomocysteinemia in Mild Cognitive Impairment, Alzheimer’s Disease, and Other Dementing Disorders. J Nutr Health Aging. 2016;20(8):825-834.
Guo H, Tabara Y, Igase M, Yamamoto M, Ochi N, Kido T, Uetani E, Taguchi K, Miki T, Kohara K. Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly: the J-SHIPP study. Hypertens Res. 2010;33(1):32-6.
Kido T, Tabara Y, Igase M, Ochi N, Uetani E, Nagai T, Yamamoto M, Taguchi K, Miki T, Kohara K. Postural instability is associated with brain atrophy and cognitive impairment in the elderly: the J-SHIPP study. Dement Geriatr Cogn Disord. 2010;29(5):379-87.
Kamogawa K, Kohara K, Tabara Y, Uetani E, Nagai T, Yamamoto M, Igase M, Miki T. Abdominal fat, adipose-derived hormones and mild cognitive impairment: the J-SHIPP study. Dement Geriatr Cogn Disord. 2010;30(5):432-9.

Conference Presentations
Embic’s scientific activities are shared at many International Conferences.

Selected List

Hara J, Bock J, Shah K, Fortier D, Lee M. Calculating Generalized Recall Probability Using Digital Cognitive Biomarkers Derived from Wordlist Memory Test Assessment. Clinical Trials on Alzheimer’s Disease, Poster Presentation, San Francisco, November 2022.
Bock J, Hara J, Fortier D, Mangrola T, Shankle W, Lee M. Digital Cognitive Biomarkers for the ADAS-Cog Word Recall Test: Accuracy and Validity of Classifying Cognitive Impairment. Clinical Trials on Alzheimer’s Disease, Poster Presentation, San Francisco, November 2022.
Bock J, Hara J, Fortier D, Albala B. Characterizing Cognitive Changes in Early-Stage Alzheimer’s Disease using Latent Cognitive Measures from the ADNI Dataset. Clinical Trials on Alzheimer’s Disease, Poster Presentation, San Francisco, November 2022.
Bock JR, Lee MD, Shankle WR, Hara J, Fortier D, Mangrola T. Detection of Pre-clinical Alzheimer’s Disease with Simultaneous Modeling of Underlying Cognitive Processes in Recall and Recognition Tests. Clinical Trials on Alzheimer’s Disease, Poster Presentation, Boston, November 2021.
Bock JR, Lee MD, Westfall H, Hara, J, Fortier D, Mangrola T, Shankle WR, Modeling Cognitive Processes with Shuffled- and Fixed-order Multi-trial Wordlist Memory Tests, Alzheimer’s Association’s International Conference (Virtual), Poster/Video Presentation, July 2021.
Bock JR, Lee MD, Shankle WR, Hara J, Fortier D, Mangrola T. Toward Discriminating Alzheimer’s Disease from Other Dementing Disorders with Modeled Cognitive Processes. Clinical Trials on Alzheimer’s Disease (Virtual), Poster Presentation, November 2020.
Bock JR, Lee MD, Hara J, Fortier D, Mangrola T, Shankle WR. Validating Digital Cognitive Biomarkers for Alzheimer’s Disease. Alzheimer’s Association’s International Conference (Virtual), Poster/Video Presentation, July 2020.
Westfall HA, Lee MD. Can we create a model of triadic comparison of animal names? 57th Edwards Bayesian Conference, Fullerton, CA, February 2020.
Lee MD, Westfall HA. A model of triadic comparison applied to the problem of understanding semantic memory impairment. Australasian Mathematical Psychology Conference, Sydney, February 2020.
Westfall H, Bock JR, Mangrola T, Lee MD. Changes in semantic memory due to cognitive impairment in Alzheimer’s disease. Clinical Trials on Alzheimer’s Disease 2019. Poster Presentation. San Diego. December 2019.
Lee MD, Bock JR, Shankle WR, Hara J, Fortier D, MangrolaM, Petersen RC. Using Hierarchical Bayesian Cognitive Processing and Latent-Mixture Models to Predictive Impending Cognitive Decline with Common Memory Tests. Clinical Trials on Alzheimer’s Disease 2019. Poster Presentation. San Diego. December 2019.
Westfall H, Bock JR, Mangrola T, Lee MD. Changes in semantic structure and free recall due to cognitive impairment and normal cognitive aging. Poster Presentation. Alzheimer’s Association’s International Conference, Los Angeles, July 2019.
Roach JC, Hara J, Lovejoy J, Fridman D, Funk C, Heath L, Price ND, Hood L, Heim L, Brant-Zawadski M, Shankle WR. Coaching for Cognition in Alzheimer’s (COCOA) Trial. Poster Presentation. Alzheimer’s Association’s International Conference, Los Angeles, July 2019.
Hara J, Brant-Zawadzki M, Keeble C, Olver B, Fortier D, Bock J, Nyugen N, Hittleman K, Porter S, Mangrola T, Shankle WR. Population Based Cognitive Health Program: Learnings from the Orange County Vital Brain Aging Program. Poster Presentation. Alzheimer’s Association’s International Conference, Los Angeles, July 2019.
BockJR, LeeMD, HaraJ, FortierD, MangrolaT, Shankle WR. Preliminary Study: Hierarchical Bayesian Cognitive Processing Model Classification of CSF and PET Amyloid Positivity and Negativity from Cognitive Assessment Data. Poster Presentation. Alzheimer’s Association’s International Conference, Los Angeles, July 2019.
Westfall HA, Lee MD. Changes in semantic memory due to cognitive impairment in Alzheimer’s patients. Annual Meeting of the Society for Mathematical Psychology, Montreal, July 2019.
Westfall HA, Bock JR, Mangrola T, Lee MD. Changes in semantic structure and free recall due to cognitive impairment and normal cognitive aging. Joint Cognitive Modeling Symposium, National Autonomous University of Mexico (UNAM), Mexico City, March 2019.